PRE-CLINICAL EVALUATION OF CD38 CHIMERIC ANTIGEN RECEPTOR ENGINEERED T CELLS FOR THE TREATMENT OF MULTIPLE MYELOMA

Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma

Adoptive transfer of chimeric antigen receptor-transduced T cells is a promising strategy for cancer immunotherapy.The CD38 molecule, with its high expression on multiple myeloma cells, appears a suitable target for 15" Cooktop antibody therapy.Prompted by this, we used three different CD38 antibody sequences to generate second-generation retrovira

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Trial evaluation of bone marrow derived mesenchymal stem cells (MSCs) transplantation in revival of spermatogenesis in testicular torsion

Defective spermatogenesis due to the failure in germ cell proliferation and differentiation is the major sign of male infertility pathogenesis; and male factor is involved in up to half of all infertile couples.Testicular torsion is an acute vascular event causing the rotation of the vascular pedicle of the testis, thereby impeding the blood flow t

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The influence of obstructive sleep apnea on self-perceived dental aesthetics and need for orthodontic treatment among the general population in Makkah, Saudi Arabia

OBJECTIVE: To assess the influence of obstructive sleep apnea on self-perceived dental appearance and need for orthodontic treatment.MATERIALS AND METHODS: A Seasonal Décor self-administered questionnaire was used in a random sample of a general adult population in Makkah region, Saudi Arabia.A total of 1014 participants completed the questionnair

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